Modeling tissue morphogenesis and cancer in 3D

Cell. 2007 Aug 24;130(4):601-10. doi: 10.1016/j.cell.2007.08.006.


Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors. These models may help to accelerate translational research in cancer biology and tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Culture Techniques
  • Humans
  • Imaging, Three-Dimensional / methods*
  • Models, Biological*
  • Morphogenesis*
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Organ Culture Techniques
  • Tumor Cells, Cultured