Apparent diffusion coefficient of pituitary macroadenoma evaluated with line-scan diffusion-weighted imaging

J Neuroradiol. 2007 Oct;34(4):228-35. doi: 10.1016/j.neurad.2007.06.007. Epub 2007 Aug 24.


Objective: The goal of this study was to evaluate the consistency of pituitary macroadenoma using apparent diffusion coefficient (ADC) with line-scan diffusion-weighted imaging (LSDWI).

Methods: Patients with pituitary macroadenoma (n=19) were studied prospectively. The LSDWI was performed using a maximum b factor of 1000 s/mm2. The consistency of macroadenoma was rated as soft, intermediate or hard at transsphenoidal surgery. The ADC values of tumors were compared with the tumor-consistency ratings.

Results: A soft consistency was found at surgery in 13 patients (mean ADC: 0.84+/-0.1x10(-3) mm2/s); an intermediate consistency was observed in six patients (mean ADC: 0.81+/-0.16x10(-3) mm2/s). No tumors of hard consistency were found. There was no significant difference in ADC values between tumors of soft consistency compared with tumors of intermediate consistency (P=0.37).

Conclusions: A relationship between tumor consistency and the ADCs of soft and intermediate macroadenomas was not shown in this study using LSDWI.

MeSH terms

  • Adenoma / metabolism*
  • Adenoma / pathology*
  • Adenoma / surgery
  • Anisotropy
  • Diffusion Magnetic Resonance Imaging*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Pituitary Neoplasms / metabolism*
  • Pituitary Neoplasms / pathology*
  • Pituitary Neoplasms / surgery
  • Prospective Studies