A randomized, controlled trial of tonsillectomy in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome

J Pediatr. 2007 Sep;151(3):289-92. doi: 10.1016/j.jpeds.2007.03.015. Epub 2007 Jun 14.


Objective: We carried out a prospective, randomized, controlled trial to clarify the effect of tonsillectomy on the clinical course of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome.

Study design: Twenty-six consecutive children (mean age 4.1 years) with at least 5 PFAPA attacks were recruited from 3 tertiary care pediatric hospitals during 1999-2003 and randomly allocated to tonsillectomy or follow-up alone. They were all followed up with symptom diaries for 12 months. Tonsillectomy was allowed after 6 months in the control group if the attacks recurred.

Results: Six months after randomization all 14 children in the tonsillectomy group and 6/12 children in the control group (50%) were free of symptoms (difference 50%, 95% confidence interval 23% to 75%, P < .001). Tonsillectomy was performed on 5/6 of the patients in the control group who still had symptoms after 6 months. The remaining unoperated child in the control group had recurrences of the fever episodes throughout the follow-up, but the symptoms became less severe, and the parents did not choose tonsillectomy.

Conclusion: Tonsillectomy appeared to be effective for treating PFAPA syndrome. The fever episodes ceased without any intervention in half of the control subjects. We conclude that although the mechanisms behind this syndrome are unknown, tonsillectomy can be offered as an effective intervention for children with PFAPA.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Child, Preschool
  • Familial Mediterranean Fever / complications
  • Familial Mediterranean Fever / surgery*
  • Female
  • Humans
  • Lymphadenitis / complications
  • Lymphadenitis / surgery*
  • Male
  • Pharyngitis / complications
  • Pharyngitis / surgery*
  • Prospective Studies
  • Recurrence
  • Stomatitis, Aphthous / complications
  • Stomatitis, Aphthous / surgery*
  • Syndrome
  • Tonsillectomy*