Chronic obstructive pulmonary disease in patients who have HIV infection

Clin Chest Med. 2007 Sep;28(3):575-87, vi. doi: 10.1016/j.ccm.2007.06.004.


An increased prevalence of chronic obstructive pulmonary disease (COPD) among persons who have HIV infection has raised the possibility that HIV may predispose to the development or progression of COPD. This article reviews the evidence that supports an association between HIV infection and COPD-namely emphysema and chronic bronchitis-and studies that suggest an association between HIV infection and small airways abnormalities and nonspecific airway hyper-responsiveness. Risk factors for COPD and potential reasons for an increased risk for COPD in HIV-positive patients are discussed. In addition, issues in the management of COPD in HIV-positive patients are reviewed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Global Health
  • HIV / immunology*
  • HIV Antibodies / immunology*
  • HIV Infections / complications*
  • HIV Infections / epidemiology
  • Humans
  • Prevalence
  • Pulmonary Disease, Chronic Obstructive / complications*
  • Pulmonary Disease, Chronic Obstructive / epidemiology
  • Risk Factors
  • Survival Rate


  • HIV Antibodies