Pyrantel in Small Animal Medicine: 30 Years On

Vet J. 2008 Nov;178(2):177-84. doi: 10.1016/j.tvjl.2007.06.021. Epub 2007 Aug 27.


Pyrantel, a tetrahydropyrimidine nicotinic agonist anthelmintic, has been used in companion animal medicine since the 1970s to control two important nematode groups, the hookworms and the roundworms. Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both companion animals and the public for more than 30 years. This review describes the history and mechanism of action of this drug, and collates evidence that resistance to pyrantel has developed in at least one canine nematode, the hookworm Ancylostoma caninum. The role of in vitro diagnosis tests in managing anthelmintic resistance in companion animal parasites is discussed, as are management practices that may reduce the rate at which resistance develops.

Publication types

  • Review

MeSH terms

  • Animals
  • Antinematodal Agents / therapeutic use*
  • Cat Diseases / drug therapy*
  • Cat Diseases / parasitology*
  • Cats
  • Dog Diseases / drug therapy*
  • Dog Diseases / parasitology*
  • Dogs
  • Nematoda / growth & development
  • Nematode Infections / drug therapy
  • Nematode Infections / parasitology
  • Nematode Infections / veterinary*
  • Pyrantel / therapeutic use*


  • Antinematodal Agents
  • Pyrantel