Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor

Jpn J Clin Oncol. 2007 Oct;37(10):793-6. doi: 10.1093/jjco/hym094. Epub 2007 Aug 24.


Granulocyte colony-stimulating factor (G-CSF)-producing malignancies are thought to be rare and associated with advanced disease and poor prognosis. Here, we report on a 77-year-old patient with G-CSF-producing gastric cancer. We observed this patient from the stage prior to the diagnosis of gastric cancer when leukocyte count was normal to the stage of advanced disease associated with remarkable leukocytosis. Immunohistochemical analysis demonstrated G-CSF expression in the advanced-stage, poorly differentiated adenocarcinoma, but not in the early-stage, well-differentiated adenocarcinoma. G-CSF receptor was not detected to be expressed in the advanced-stage tumor. Based on these results it appears that a histological change in the tumor may influence G-CSF production and the concomitant rapid progression in gastric cancer.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / surgery
  • Aged
  • Biopsy
  • Cell Transformation, Neoplastic
  • Colonic Polyps / pathology
  • Colonic Polyps / surgery
  • Disease Progression
  • Fatal Outcome
  • Granulocyte Colony-Stimulating Factor / biosynthesis*
  • Humans
  • Immunohistochemistry
  • Male
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / metabolism*
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Staging
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery


  • Granulocyte Colony-Stimulating Factor