Modelling breast cancer: one size does not fit all

Nat Rev Cancer. 2007 Sep;7(9):659-72. doi: 10.1038/nrc2193.


Breast cancer is not a single disease, but is instead a collection of diseases that have distinct histopathological features, genetic and genomic variability, and diverse prognostic outcomes. Thus, no individual model would be expected to completely recapitulate this complex disease. Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms*
  • Cell Line, Tumor
  • Disease Models, Animal*
  • Forecasting
  • Mice
  • Mice, Transgenic
  • Neoplasm Transplantation
  • Rats