Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

Nat Rev Cancer. 2007 Sep;7(9):673-83. doi: 10.1038/nrc2210.

Abstract

The myeloproliferative disorders polycythaemia vera (PV), essential thombocythaemia (ET), and primary myelofibrosis (PMF) are clonal disorders of multipotent haematopoietic progenitors. The genetic cause of these diseases was not known until 2005, when several independent groups demonstrated that most patients with PV, ET and PMF acquire a single point mutation in the cytoplasmic tyrosine kinase JAK2 (JAK2V617F). These discoveries have changed the landscape for diagnosis and classification of PV, ET and PMF, and show the ability of genomic technologies to identify new molecular targets in human malignancies with pathogenetic, diagnostic and therapeutic significance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Enzyme Activation
  • Forecasting
  • Humans
  • Janus Kinase 2 / antagonists & inhibitors
  • Janus Kinase 2 / genetics*
  • Janus Kinase 2 / physiology
  • Myeloproliferative Disorders / genetics*
  • Myeloproliferative Disorders / therapy*
  • Point Mutation
  • Signal Transduction
  • Transcriptional Activation

Substances

  • Janus Kinase 2