Broad HIV-1 neutralization mediated by CD4-binding site antibodies

Nat Med. 2007 Sep;13(9):1032-4. doi: 10.1038/nm1624. Epub 2007 Aug 26.


We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / blood
  • Acquired Immunodeficiency Syndrome / immunology*
  • Antigens, CD / immunology
  • Binding Sites, Antibody
  • CD4 Antigens / immunology*
  • Cohort Studies
  • HIV Antibodies / immunology
  • HIV-1 / immunology*
  • Humans
  • Neutralization Tests


  • Antigens, CD
  • CD4 Antigens
  • HIV Antibodies