Organochlorines and risk of non-Hodgkin lymphoma

Int J Cancer. 2007 Dec 15;121(12):2767-75. doi: 10.1002/ijc.23005.


Organochlorine chemicals and polychlorinated biphenyls (PCBs) have been suspected as possible risk factors for non-Hodgkin lymphoma (NHL). We investigated PCBs and organochlorine pesticides and risk of NHL in a population-based case-control study in British Columbia, Canada. Congeners of PCBs (including dioxinlike congeners) and pesticides or pesticide metabolites were measured in plasma of 422 pretreatment cases and 460 control subjects. This is so far the largest study to examine organochlorines in plasma to date. Several dioxin-like PCB congeners were associated with increased risk of NHL, including dioxin-like PCB nos. 118 and 156 with odds ratios (OR) for the highest versus lowest quartile between 1.6 and 1.8. Several non-dioxin-like congeners also showed significant associations. The PCB congener with the strongest association was no. 180 with an OR for the highest versus the lowest quartile of 1.83 (95% confidence interval = 1.18-2.84). Six pesticide analytes also showed a significant association with NHL; beta-hexachlorocyclohexane, p,p'-DDE, hexachlorobenzene, mirex, oxychlordane and trans-nonachlor. The strongest association was found for oxychlordane, a metabolite of the pesticide chlordane (highest vs. lowest quartile OR = 2.68, 95% confidence interval = 1.69-4.24). Our results provide further evidence that organochlorines contribute to NHL risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • British Columbia / epidemiology
  • Case-Control Studies
  • Chlordan / analogs & derivatives
  • Chlordan / blood
  • Environmental Exposure / adverse effects*
  • Environmental Pollutants / blood*
  • Environmental Pollutants / toxicity
  • Female
  • Humans
  • Hydrocarbons, Chlorinated / blood
  • Lymphoma, Non-Hodgkin / blood
  • Lymphoma, Non-Hodgkin / chemically induced*
  • Lymphoma, Non-Hodgkin / epidemiology*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Pesticides / blood*
  • Pesticides / toxicity
  • Polychlorinated Biphenyls / blood*
  • Polychlorinated Biphenyls / toxicity
  • Registries
  • Risk Assessment
  • Risk Factors
  • Statistics, Nonparametric


  • Environmental Pollutants
  • Hydrocarbons, Chlorinated
  • Pesticides
  • Chlordan
  • oxychlordane
  • Polychlorinated Biphenyls