Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006;1(4):411-6.
doi: 10.2147/nano.2006.1.4.411.

Megestrol Acetate in Cachexia and Anorexia

Free PMC article

Megestrol Acetate in Cachexia and Anorexia

Shing-Shing Yeh et al. Int J Nanomedicine. .
Free PMC article


The aim is to review major clinical trials that have used megestrol acetate (MA) in the treatment of cachexia across several disease states. A review of general usage and potential side-effects are discussed. A theory that the newly approved nanocrystal formation of MA can better deliver this potent medication for treatment will also be reviewed.


Figure 1
Figure 1
Summary of proposed megestrol acetate (MA) mechanism for weight gain and potential side-effects. Abbreviations: CA, cancer; Con A, concanavalin A; HTN, hypertension; MA, megestrol acetate; Pha, phytohemagglutinin; PIC, pro-inflammatory cytokine; RX: treatment; S O WB, sense of well being; Sti, stimulation; WT, weight.

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles


    1. Alakhov V, Pietrzynski G, Patel K, et al. Pluronic block copolymers and Pluronic poly(acrylic acid) microgels in oral delivery of megestrol acetate. J Pharm Pharmacol. 2004;56:1233–41. - PubMed
    1. Barak V, Schwartz A, Kalickman I, et al. Prevalence of hypophosphatemia in sepsis and infection: the role of cytokines. Am J Med. 1998;104:40–7. - PubMed
    1. Bennett RG. 2003Megestrol complications Chest 123309– reply 310. - PubMed
    1. Berenstein E, Ortiz Z. Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2005:CD004310. - PubMed
    1. Bojar H, Maar K, Staib W. The endocrine background of human renal cell carcinoma. IV. Glucocorticoid receptors as possible mediators of progestogen action. Urol Int. 1979;34:330–8. - PubMed

MeSH terms

LinkOut - more resources