Discovery and development of sulforaphane as a cancer chemopreventive phytochemical

Acta Pharmacol Sin. 2007 Sep;28(9):1343-54. doi: 10.1111/j.1745-7254.2007.00679.x.


Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis. We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / isolation & purification
  • Anticarcinogenic Agents / metabolism
  • Anticarcinogenic Agents / pharmacology
  • Anticarcinogenic Agents / therapeutic use*
  • Humans
  • Isothiocyanates
  • Neoplasms / prevention & control*
  • Thiocyanates / isolation & purification
  • Thiocyanates / metabolism
  • Thiocyanates / pharmacology
  • Thiocyanates / therapeutic use*


  • Anticarcinogenic Agents
  • Isothiocyanates
  • Thiocyanates
  • sulforaphane