Islet beta-cell death - fuel to sustain autoimmunity?

Immunity. 2007 Aug;27(2):183-5. doi: 10.1016/j.immuni.2007.08.002.

Abstract

Under what context do dying beta-cells enhance the autoimmune process in type 1 diabetes? Kim et al. (2007) find that secondary necrosis of beta-cells can prime the autoimmune response via uptake by and activation of antigen-presenting cells through Toll-like receptor 2.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Apoptosis
  • Autoimmunity / immunology*
  • Diabetes Mellitus, Type 1 / immunology*
  • Insulin-Secreting Cells / immunology
  • Insulin-Secreting Cells / pathology*
  • Mice
  • Necrosis
  • Toll-Like Receptor 2 / metabolism*

Substances

  • Toll-Like Receptor 2