Causality assessment of drug-induced hepatotoxicity: promises and pitfalls

Clin Liver Dis. 2007 Aug;11(3):477-505, v. doi: 10.1016/j.cld.2007.06.003.


Drug-induced liver injury is the leading cause of acute liver failure in the United States, but the ability to ascribe hepatic injury confidently to a specific drug remains a challenging and often difficult pursuit. This article explores the ongoing challenges inherent in what is currently a clinical process of elimination made in the attempt of assigning causality in drug-induced liver injury. In particular, it points out the shortcomings and pitfalls that often limit the applicability of the causality-assessment methodologies currently in use.

Publication types

  • Review

MeSH terms

  • Causality
  • Chemical and Drug Induced Liver Injury*
  • Drug-Related Side Effects and Adverse Reactions*
  • Female
  • Humans
  • Liver / drug effects
  • Liver / metabolism
  • Liver / pathology
  • Male