Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006;18(1-2):113-24.
doi: 10.1615/critrevneurobiol.v18.i1-2.120.

Endocannabinoid Signaling and Synaptic Plasticity in the Brain

Affiliations
Review

Endocannabinoid Signaling and Synaptic Plasticity in the Brain

Ping Jun Zhu. Crit Rev Neurobiol. .

Abstract

Repetitive firing neuron or activation of synaptic transmission plays an important role in the modulation of synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD). These activity-dependent changes in synaptic efficacy are thought to be critical to learning and memory; however, the underlying mechanisms remain to be defined. Endogenous cannabinoids (eCBs) are diffusible modulators that are released from depolarized postsynaptic neurons and act on presynaptic terminals. Persistent release of eCBs can lead to long-term modulation of synaptic plasticity in the brain. Given a broad distribution of eCB receptors in the brain, the eCB signaling system could contribute to use-dependent modification of brain functions.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback