Brain tumours and the occurrence of severe invasive basal cell carcinoma in first degree relatives with Gorlin syndrome

Br J Neurosurg. 1991;5(6):643-6. doi: 10.3109/02688699109002890.

Abstract

We describe the occurrence of a medulloblastoma and an astrocytoma in successive generations of a family with the Gorlin syndrome. The appearance of thousands of invasive basal cell carcinomata after craniospinal irradiation led to the death of one patient from intracranial involvement.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Astrocytoma / pathology
  • Basal Cell Nevus Syndrome / genetics*
  • Basal Cell Nevus Syndrome / pathology
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology
  • Carcinoma, Basal Cell / etiology
  • Carcinoma, Basal Cell / genetics*
  • Carcinoma, Basal Cell / pathology
  • Cerebellar Neoplasms / pathology
  • Cerebellar Neoplasms / radiotherapy
  • Humans
  • Male
  • Medulloblastoma / pathology
  • Medulloblastoma / radiotherapy
  • Neoplasms, Radiation-Induced / pathology
  • Radiotherapy / adverse effects
  • Skin Neoplasms / etiology
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology