Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation

Cell Cycle. 2007 Oct 15;6(20):2440-4. doi: 10.4161/cc.6.20.4786. Epub 2007 Jul 23.

Abstract

The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates beta2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.

MeSH terms

  • Animals
  • Cell Adhesion
  • Disease Progression
  • Enzyme Activation
  • Humans
  • Mitogen-Activated Protein Kinases / metabolism*
  • Neoplasm Proteins / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Signal Transduction*

Substances

  • Neoplasm Proteins
  • beta-chimaerin
  • Mitogen-Activated Protein Kinases