Abstract
Proteins follow two routes to reach the correct surface (apical or basolateral) of a polarized epithelial cell: direct sorting from the trans-Golgi network and transcytosis from early endosomes. Several signals have been identified recently that control these sorting events, namely a glycosyl-phosphatidylinositol anchor for apical targeting, a 14-residue cytoplasmic segment of the polymeric immunoglobulin receptor for basolateral targeting, and phosphorylation of a Ser residue for transcytosis of this receptor. The machinery involved is still poorly understood.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Biological Transport
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Cell Compartmentation*
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Cell Polarity*
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Cells, Cultured
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Dogs
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Endocytosis
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Epithelium / metabolism*
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Epithelium / ultrastructure
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GTP Phosphohydrolases / metabolism
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Golgi Apparatus / metabolism
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Kidney / metabolism
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Liver / metabolism
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Lysosomes / metabolism
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Membrane Proteins / metabolism*
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Mice
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Models, Biological
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Phosphorylation
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Protein Processing, Post-Translational
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Receptors, Immunologic
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Secretory Component / metabolism
Substances
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Membrane Proteins
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Receptors, Immunologic
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Secretory Component
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GTP Phosphohydrolases