Quinic acid esters from Pluchea indica with collagenase, MMP-2 and MMP-9 inhibitory activities

Phytother Res. 2008 Feb;22(2):264-6. doi: 10.1002/ptr.2290.

Abstract

Investigation of collagenase inhibitory natural components afforded two quinic acid esters (1 and 2) and quercetin (3) from the leaves of Pluchea indica (Compositae). Of these, compounds 1 and 2 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 10 microm, and 1 showed matrix metalloproteinase (MMP)-2 and -9 inhibitory activity (IC(50)) at 2.5 and 6.4 microm, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asteraceae / chemistry*
  • Dose-Response Relationship, Drug
  • Esters
  • Matrix Metalloproteinase Inhibitors*
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Quinic Acid / chemistry
  • Quinic Acid / pharmacology*

Substances

  • Esters
  • Matrix Metalloproteinase Inhibitors
  • Plant Extracts
  • Quinic Acid