Long lasting BCG protection against leprosy

Vaccine. 2007 Sep 28;25(39-40):6842-4. doi: 10.1016/j.vaccine.2007.07.032. Epub 2007 Aug 6.

Abstract

Background: BCG vaccine protects against leprosy.

Objectives: Estimate BCG protection against leprosy by age by age.

Methods: A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.

Results: BCG protection against leprosy was 86% (95% CI: 77-92%) in the age group 18-29; 54% (95% CI: -37% to 85%) in the age group 30-39 and 32% (95% CI: -3% to 56%) in those aged 40 or more.

Conclusions: BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • BCG Vaccine / administration & dosage*
  • BCG Vaccine / therapeutic use*
  • Brazil / epidemiology
  • Case-Control Studies
  • Humans
  • Incidence
  • Leprosy / epidemiology
  • Leprosy / microbiology
  • Leprosy / prevention & control*
  • Mycobacterium leprae / immunology
  • Sensitivity and Specificity
  • Time Factors
  • Treatment Outcome
  • Vaccination*

Substances

  • BCG Vaccine