Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 30 (5), 390-7

Optimal Management of Urosepsis From the Urological Perspective

Affiliations
Review

Optimal Management of Urosepsis From the Urological Perspective

Florian M E Wagenlehner et al. Int J Antimicrob Agents.

Abstract

Urosepsis in adults comprises approximately 25% of all sepsis cases and in most cases is due to complicated urinary tract infections (UTIs). In this paper we review the optimal management of urosepsis from the urological point of view. Urosepsis is often due to obstructed uropathy of the upper or lower urinary tract. The treatment of urosepsis comprises four major aspects: 1. Early goal-directed therapy; 2. Optimal pharmacodynamic exposure to antimicrobials both in blood and in the urinary tract; 3. Control of complicating factors in the urinary tract; 4. Specific sepsis therapy. Early tissue oxygenation, appropriate initial antibiotic therapy and rapid identification and control of the septic focus in the urinary tract are critical steps in the successful management of a patient with severe urosepsis. To achieve this goal an optimal interdisciplinary approach encompassing the emergency unit, urological specialties and intensive-care medicine is necessary.

Similar articles

  • Diagnosis and Management for Urosepsis
    FM Wagenlehner et al. Int J Urol 20 (10), 963-70. PMID 23714209. - Review
    Urosepsis is defined as sepsis caused by a urogenital tract infection. Urosepsis in adults comprises approximately 25% of all sepsis cases, and is in most cases due to co …
  • Therapeutic Challenges of Urosepsis
    FM Wagenlehner et al. Eur J Clin Invest 38 Suppl 2, 45-9. PMID 18826481. - Review
    Urosepsis accounts for approximately 25% of all sepsis cases and may develop from a community or nosocomial acquired urinary tract infection (UTI). The underlying UTI is …
  • Urosepsis--from the View of the Urologist
    FM Wagenlehner et al. Int J Antimicrob Agents 38 Suppl, 51-7. PMID 21993485. - Review
    Urosepsis accounts for approximately 25% of all sepsis cases and may develop from a community-or nosocomial-acquired urinary tract infection (UTI). The underlying UTI is …
  • Pharmacokinetic Characteristics of Antimicrobials and Optimal Treatment of Urosepsis
    FM Wagenlehner et al. Clin Pharmacokinet 46 (4), 291-305. PMID 17375981. - Review
    Urosepsis accounts for approximately 25% of all sepsis cases and may develop from a community-acquired or nosocomial urinary tract infection (UTI). Nevertheless, the unde …
  • Urosepsis: From the Intensive Care Viewpoint
    G Marx et al. Int J Antimicrob Agents 31 Suppl 1, S79-84. PMID 18053691.
    A recent survey conducted by the Competence Network Sepsis (SepNet) revealed that severe sepsis and/or septic shock occurs in 75000 inhabitants (110 per 100,000) and seps …
See all similar articles

Cited by 14 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback