Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

Neuropsychopharmacology. 2008 Jan;33(1):18-41. doi: 10.1038/sj.npp.1301559. Epub 2007 Aug 29.

Abstract

Experiences, whether they be learning in a classroom, a stressful event, or ingestion of a psychoactive substance, impact the brain by modifying the activity and organization of specific neural circuitry. A major mechanism by which the neural activity generated by an experience modifies brain function is via modifications of synaptic transmission; that is, synaptic plasticity. Here, we review current understanding of the mechanisms of the major forms of synaptic plasticity at excitatory synapses in the mammalian brain. We also provide examples of the possible developmental and behavioral functions of synaptic plasticity and how maladaptive synaptic plasticity may contribute to neuropsychiatric disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Models, Neurological
  • Neuronal Plasticity / physiology*
  • Neurons / physiology*
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Synapses / physiology*
  • Synaptic Transmission / physiology

Substances

  • Receptors, N-Methyl-D-Aspartate