HDL-inflammatory index correlates with poor outcome in hemodialysis patients

Kidney Int. 2007 Nov;72(9):1149-56. doi: 10.1038/sj.ki.5002491. Epub 2007 Aug 29.


Oxidative stress and cardiovascular disease are risk factor of patients with chronic kidney disease (CKD) on maintenance hemodialysis. We used the fluorescence of low-density lipoprotein as an index of its proinflammatory potential to examine any role that high-density lipoprotein (HDL) might have in promoting this effect. The total body fat of the patients was measured by means of near-infrared interactance and their quality of life by means of SF36 questionnaires. In 189 randomly selected patients, followed for 30 months, HDL was found to be significantly anti-inflammatory but with a large standard deviation. Fully 17% of the patients had a decidedly proinflammatory index along with inferior SF36 scores. The patients were divided into 10% increments of total body fat percentages up to 40%. HDL was found to be progressively proinflammatory the higher the body fat content. Patients with a higher HDL proinflammatory index had a higher 30-month adjusted hazard ratio for death than those whose HDL were seen to be anti-inflammatory. Our findings suggest an important role of inflammatory HDL in patients with CKD leading to poor outcome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Body Composition / physiology
  • Chronic Disease
  • Female
  • Follow-Up Studies
  • Health Surveys
  • Humans
  • Inflammation
  • Kaplan-Meier Estimate
  • Kidney Diseases / blood*
  • Kidney Diseases / diagnosis
  • Kidney Diseases / therapy*
  • Lipoproteins, HDL / blood*
  • Male
  • Middle Aged
  • Oxidative Stress / physiology
  • Prognosis
  • Quality of Life
  • Renal Dialysis*
  • Risk Factors
  • Treatment Outcome


  • Biomarkers
  • Lipoproteins, HDL