Hereditary deafness occurring in cd/1 mice

Hear Res. 1991 Dec;57(1):153-6. doi: 10.1016/0378-5955(91)90084-m.


Different strains of mice provide a valuable research tool for studying both hereditary and acquired forms of deafness. The cd/1 strain has been found to demonstrate hereditary cochlear pathology. The characteristics of hearing loss in cd/1 mice have not previously been reported. In this investigation auditory thresholds were obtained by measuring evoked brain stem responses in subjects of three different ages: 3 weeks, 10 weeks and 6 months. The results were compared with thresholds obtained from CBA/Ca mice (which have normal hearing) and C57BL/6 mice (which are known to have a genetically determined pre-senile progressive cochlear hearing loss). A significant hearing loss was observed which progressed from high to low frequencies, and with age. Extensive degeneration was observed throughout the organ of Corti. cd/1 mice may provide a useful model for studying genetically determined deafness.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Auditory Threshold
  • Cochlea / ultrastructure
  • Deafness / genetics*
  • Deafness / pathology
  • Deafness / physiopathology
  • Disease Models, Animal
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Microscopy, Electron, Scanning
  • Species Specificity