The effect on serum lipid concentrations of a prolonged infusion of propofol--hypertriglyceridaemia associated with propofol administration

Intensive Care Med. 1991;17(7):424-6. doi: 10.1007/BF01720682.

Abstract

Serum concentrations of triglyceride, cholesterol and high density lipoprotein-cholesterol (HDL-cholesterol) were measured in an ICU patient after he had received a 10-day continuous infusion of propofol. No additional parenteral lipid was given in the 72 h prior to initial sampling, but a total of 71 of 10% intralipid had been administered over the remaining 7 days. The total cumulative dose of propofol was 66.1 g (range 0.7-6.4 mg kg-1 h-1). There was no visual appearance of lipaemia. Both the serum triglyceride and cholesterol concentrations increased (triglyceride level increased to 4 times normal whereas the cholesterol elevation was minimal). The HDL-cholesterol concentration decreased. At 72 h after discontinuing the infusion of propofol the triglyceride level remained elevated, the cholesterol concentration had returned to normal and the HDL-cholesterol concentration remained unchanged. The implications of hypertriglyceridaemia are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Energy Intake
  • Fat Emulsions, Intravenous / standards
  • Humans
  • Hypertriglyceridemia / blood
  • Hypertriglyceridemia / chemically induced*
  • Infusions, Intravenous
  • Male
  • Multiple Trauma / drug therapy*
  • Multiple Trauma / therapy
  • Propofol / administration & dosage
  • Propofol / adverse effects*
  • Triglycerides / blood

Substances

  • Cholesterol, HDL
  • Fat Emulsions, Intravenous
  • Triglycerides
  • Cholesterol
  • Propofol