Sedation by propofol in tetanus--is it a muscular relaxant?

Intensive Care Med. 1991;17(7):427-9. doi: 10.1007/BF01720683.


We investigated the muscular relaxant properties of propofol in a 54 year-old-man with severe tetanus. Four consecutive boluses of propofol 50 mg i.v. were administered. Mean muscular activity recorded on an electromyography (EMG) decreased from 100 to 10-25 mV within 15 s after each bolus. EMG values were restored to prior levels 10 min after the last bolus. Maximum decrease of muscular activity was observed with propofol blood level between 2.90-3.20 Neuromuscular function recorded by means of evoked electromyography was not affected by propofol administration.

Publication types

  • Case Reports

MeSH terms

  • Electroencephalography / drug effects
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Propofol / blood
  • Propofol / pharmacology
  • Propofol / therapeutic use*
  • Tetanus / complications*
  • Trismus / blood
  • Trismus / drug therapy*
  • Trismus / etiology


  • Propofol