Enhancement of memory retrieval and attenuation of scopolamine-induced amnesia following administration of 5-HT3 antagonist ICS 205-930

Pharmacol Toxicol. 1991 Aug;69(2):105-6. doi: 10.1111/j.1600-0773.1991.tb01280.x.

Abstract

Experimental evidence suggests an important role of serotonin in the process of learning and memory. The present study investigated the effect of 5HT3-receptor antagonist (ICS 205-930) on retrieval of a previously learned aversive habit in the mouse. The effect of ICS 205-930 on scopolamine (3 mg/kg) induced amnesia was also studied. ICS 205-930 (1, 10 & 100 micrograms/kg) produced a dose-dependent increase in latency to cross into the dark chamber. The scopolamine induced memory impairment was significantly attenuated by ICS 205-930 (10 micrograms/kg). These results suggest that memory deficits may be susceptible to attenuation with non-cholinergic treatments.

MeSH terms

  • Amnesia / chemically induced
  • Amnesia / drug therapy*
  • Animals
  • Indoles / pharmacology*
  • Learning / drug effects
  • Male
  • Memory / drug effects*
  • Memory Disorders / chemically induced
  • Memory Disorders / drug therapy
  • Mice
  • Scopolamine
  • Serotonin Antagonists / pharmacology*
  • Tropisetron

Substances

  • Indoles
  • Serotonin Antagonists
  • Tropisetron
  • Scopolamine