[Pathomorphological assessment of the therapeutic effect of mycobacteriophages in tuberculosis]

Probl Tuberk. 1991;(11):63-6.
[Article in Russian]

Abstract

The effect of DS6A mycophage was studied in comparison with that of isoniazid on 30 guinea pigs with disseminated tuberculous infection in order to reveal the therapeutic effect of the mycobacteriophage and tissue reactions caused by it. The mycophage was found to have therapeutic properties in disseminated tuberculosis in guinea pigs but its action is less pronounced than in isoniazid monotherapy. Study of the special features of tissue reactions in mycophage monotherapy has demonstrated that with the mycophage phagocytosis remains incomplete and granulomatous processes that gradually lose morphological signs of tuberculous inflammation and acquire typical features of sarcoidosis develop in the animal organs.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Isoniazid / therapeutic use
  • L Forms / isolation & purification
  • Lung / microbiology
  • Lung / pathology
  • Lung Diseases / pathology
  • Mycobacteriophages*
  • Mycobacterium tuberculosis / isolation & purification
  • Phagocytosis
  • Rabbits
  • Sarcoidosis / pathology
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / pathology
  • Tuberculosis, Pulmonary / therapy*

Substances

  • Isoniazid