Lack of amiloride sensitivity in SHR and WKY glossopharyngeal taste responses to NaCl

Physiol Behav. 1991 Oct;50(4):765-9. doi: 10.1016/0031-9384(91)90015-g.

Abstract

To explore possible functional strain differences in taste receptors located on the posterior tongue, we recorded electrophysiological taste responses from the glossopharyngeal nerve of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Multifiber responses to a concentration series (0.5 M to 2.0 M) of NaCl, KCl and NH4Cl were recorded before and after lingual application of the epithelial sodium transport blocker, amiloride. Responses to a concentration series (0.0025 M to 0.1 M) of quinine hydrochloride were also recorded. When expressed relative to the 0.5-M NH4Cl response, responses to the monochloride salts were equivalent between SHR and WKY. Surprisingly, NaCl responses were not suppressed by the sodium transport blocker, amiloride. This is in direct contrast to the dramatic suppression observed in the chorda tympani. Also, relative responses to quinine were greater in the glossopharyngeal nerve of SHR than WKY. These results indicate that taste receptors innervated by the glossopharyngeal nerve lack amiloride sensitivity and that posterior taste receptor function to monochloride salts is equivalent between SHR and WKY.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amiloride / pharmacology*
  • Animals
  • Blood Pressure / drug effects*
  • Evoked Potentials / drug effects
  • Glossopharyngeal Nerve / drug effects*
  • Male
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Sodium Chloride / pharmacology*
  • Taste / drug effects*
  • Taste Buds / drug effects
  • Tongue / innervation

Substances

  • Sodium Chloride
  • Amiloride