Eradication of Helicobacter pylori infection equally improves chronic urticaria with positive and negative autologous serum skin test

Helicobacter. 2007 Oct;12(5):567-71. doi: 10.1111/j.1523-5378.2007.00522.x.


Background: The aim of the study was to examine effects of Helicobacter pylori eradication on chronic idiopathic urticaria (CU) with and without positive aulogous serum skin test (ASST).

Methods: Seventy-eight patients with CU were checked for the positivity ASST and H. pylori urea (13)C-urea breath test ((13)C-UBT). Twenty-one patients were with both positive ASST and positive (13)C-UBT (group A), and 24 patients were with negative ASST and positive (13)C-UBT (group B). All patients with positive (13)C-UBT received a 14-day, open treatment with amoxicillin 1 g b.i.d., clarithromycin 500 mg b.i.d., and omeprazole 20 mg b.i.d. H. pylori eradication was assessed by a second (13)C-UBT after 8 weeks. In control group, 33 patients with CU were included. The effect of H. pylori eradication on CU was evaluated by urticaria activity score (UAS), measured at study entry and at 8 and 16 weeks.

Results: At week 8, baseline UAS reduced from 4.7 +/- 1.1 to 2.4 +/- 1.4 (p = .027) in group A and from 4.3 +/- 1.5 to 2.3 +/- 1.2 (p = .008) in group B, without statistically significant difference between the two groups. In control group and in six patients with H. pylori eradication failure, no changes of UAS were noted.

Conclusion: Eradication of H. pylori infection by triple therapy significantly and equally reduces UAS in CU patients with positive and negative ASST.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Amoxicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Ulcer Agents / therapeutic use*
  • Autoantibodies / blood
  • Chronic Disease
  • Clarithromycin / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Helicobacter Infections / complications*
  • Helicobacter Infections / drug therapy*
  • Helicobacter Infections / immunology
  • Helicobacter pylori / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Omeprazole / therapeutic use
  • Skin Tests / methods*
  • Treatment Outcome
  • Urticaria / complications*
  • Urticaria / immunology


  • Anti-Bacterial Agents
  • Anti-Ulcer Agents
  • Autoantibodies
  • Amoxicillin
  • Clarithromycin
  • Omeprazole