Dysregulation of CD47 and the ligands thrombospondin 1 and 2 in multiple myeloma

Br J Haematol. 2007 Sep;138(6):756-60. doi: 10.1111/j.1365-2141.2007.06729.x.


CD47 and thrombospondin 1 and 2 (TSP1 and TSP2) expression were analysed by real-time reverse transcription polymerase chain reaction in fluorescence-activated cell sorted plasma cells (PCs) from patients at consecutive stages of multiple myeloma (MM) development. 80% of MM patients, but only 39% of patients with monoclonal gammopathy of undetermined significance (MGUS) expressed CD47; median expression level increased 10-fold with progression from MGUS to MM. Elevated TSP1/TSP2 levels occurred in bone marrow cultures from MM patients compared with healthy donors. CD47 and TSP1/TSP2 may have a potential role in the pathophysiology of MM, probably in the interaction between MM PCs and the microenvironment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Marrow Examination
  • CD47 Antigen / genetics*
  • Case-Control Studies
  • Chi-Square Distribution
  • Disease Progression
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunophenotyping
  • Middle Aged
  • Multiple Myeloma / immunology*
  • Multiple Myeloma / mortality
  • Paraproteinemias / immunology
  • Plasma Cells / immunology*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Statistics, Nonparametric
  • Survival Analysis
  • Thrombospondin 1 / genetics*
  • Thrombospondins / genetics*


  • CD47 Antigen
  • Thrombospondin 1
  • Thrombospondins
  • thrombospondin 2