Hormonal management of premenstrual syndrome

Best Pract Res Clin Obstet Gynaecol. 2008 Apr;22(2):251-60. doi: 10.1016/j.bpobgyn.2007.07.001. Epub 2007 Aug 30.


Premenstrual syndrome (PMS) is a psychological and somatic disorder of unknown aetiology. The symptoms of PMS regularly occur during the luteal phase of the menstrual cycle and resolve by the end of menstruation. The severe and predominantly psychological form of PMS is called 'premenstrual dysphoric disorder'. PMS results from ovulation and appears to be caused by the progesterone produced following ovulation in women who have enhanced progesterone sensitivity. This enhanced sensitivity may be due to neurotransmitter dysfunction. Treatment is aimed at suppressing ovulation or reducing progesterone sensitivity. This chapter will describe the role of hormones and hormonal treatments in PMS.

Publication types

  • Review

MeSH terms

  • Contraceptives, Oral, Combined / therapeutic use
  • Danazol / therapeutic use
  • Estradiol / therapeutic use
  • Estrogen Antagonists / therapeutic use
  • Female
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Hormones / therapeutic use*
  • Humans
  • Premenstrual Syndrome / diagnosis
  • Premenstrual Syndrome / drug therapy*
  • Premenstrual Syndrome / etiology
  • Progesterone / therapeutic use


  • Contraceptives, Oral, Combined
  • Estrogen Antagonists
  • Hormones
  • Gonadotropin-Releasing Hormone
  • Progesterone
  • Estradiol
  • Danazol