Regulatory crosstalk at composite response elements

Trends Biochem Sci. 1991 Nov;16(11):423-6. doi: 10.1016/0968-0004(91)90168-u.


Transcriptional regulatory factors from different families interact with each other when bound to DNA at composite response elements. This level of communication has two striking consequences: ubiquitous factors can effect cell specificity, and closely related factors from a given family can produce very different regulatory patterns.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Communication
  • DNA-Binding Proteins / genetics
  • Genes, Regulator / genetics*
  • Humans
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Transcription Factors