Transcriptional control in hepatocytes: a window on development

Trends Biochem Sci. 1991 Nov;16(11):427-30. doi: 10.1016/0968-0004(91)90169-v.


The unique phenotype of each differentiated cell in an animal (or plant) arises from selective expression of genes in a cell- or tissue-specific fashion, which is controlled primarily at the level of transcription. This review will focus on transcription factors that regulate cell-specific transcription in one intensely studied cell type, the hepatocyte or parenchymal liver cell. All of the recently isolated transcription factors that are important in hepatocyte-specific gene expression were identified in adult liver and there are strong hints that some of these may play an important role in embryogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • Enhancer Elements, Genetic / genetics
  • Gene Expression Regulation / genetics*
  • Liver / cytology*
  • Nuclear Proteins / genetics
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Nuclear Proteins
  • Transcription Factors