Feasibility of multiple-mouse dynamic contrast-enhanced MRI

Magn Reson Med. 2007 Sep;58(3):610-5. doi: 10.1002/mrm.21348.


Dynamic contrast-enhanced (DCE-) MRI is often used to evaluate the response to experimental antiangiogenic therapies in small animal models of cancer. Unfortunately, DCE-MRI studies often require a substantial investment of both time and money to achieve the desired level of statistical significance. Multiple-mouse MRI has previously been used to improve imaging efficiency, but its feasibility for DCE-MRI has not been investigated. The purpose of this work was to determine if multiple-mouse DCE-MRI is feasible when using gadolinium-based contrast agents with a low molecular weight. A population of tumor-bearing mice was scanned using two four-element arrays and a single-coil configuration on a 4.7T, 40 cm bore Bruker Biospec MRI scanner. Pharmacokinetic parameters were calculated and compared to determine if a significant difference between methodologies existed. With both four-animal imaging configurations, animal throughput accelerations of just less than three were achieved and quantitative data were not significantly different than from single-animal acquisitions.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Contrast Media* / pharmacokinetics
  • Disease Models, Animal
  • Equipment Design
  • Feasibility Studies
  • Fibrosarcoma / pathology
  • Gadolinium DTPA / pharmacokinetics
  • Image Enhancement / instrumentation
  • Image Enhancement / methods*
  • Injections, Subcutaneous
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Time Factors


  • Contrast Media
  • Gadolinium DTPA