Novel eye cream containing a mixture of human growth factors and cytokines for periorbital skin rejuvenation

J Drugs Dermatol. 2007 Jul;6(7):725-9.


Evidence of the signs associated with skin aging often first appears in the periorbital area and includes wrinkles, eyelid bags, circles around the eye, or a "tired" look. This multicenter study aimed to investigate a novel eye cream containing a proprietary mixture of human growth factors and cytokines in combination with caffeine, bisabolol, glycyrrhetinic acid, and sodium hyaluronate for periorbital rejuvenation. The study, which was completed by 37 female subjects between 36 to 65 years of age, revealed that clinical signs for wrinkles, lower eyelid bags or sagging, dark circles, and skin texture show significant improvement (average 14%-28%) after 6 weeks of twice-daily application. These clinical improvements were confirmed by a subject questionnaire. The subjects further reported that their tired look significantly improved by 32% in average. All subjects tolerated the eye cream well and liked the way it felt. The cream's efficacy, excellent tolerability in the delicate periorbital skin area, and pleasant sensory properties explain why a large majority (78%) would continue regular use.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Caffeine / chemistry
  • Emollients / chemistry
  • Emollients / pharmacology*
  • Eyelids
  • Female
  • Follow-Up Studies
  • Glycyrrhetinic Acid / chemistry
  • Humans
  • Hyaluronic Acid / chemistry
  • Middle Aged
  • Monocyclic Sesquiterpenes
  • Orbit
  • Patient Satisfaction
  • Rejuvenation*
  • Sesquiterpenes / chemistry
  • Skin Aging / drug effects*
  • Surveys and Questionnaires
  • Treatment Outcome


  • Emollients
  • Monocyclic Sesquiterpenes
  • Sesquiterpenes
  • bisabolol
  • Caffeine
  • Hyaluronic Acid
  • Glycyrrhetinic Acid