Conventional versus invaginated stripping of the great saphenous vein: a randomized, double-blind, controlled clinical trial

World J Surg. 2007 Nov;31(11):2236-42. doi: 10.1007/s00268-007-9211-3. Epub 2007 Sep 1.


Background: An invaginated strip of the great saphenous vein (GSV) may be associated with diminished blood loss and less discomfort compared to conventional stripping in patients with unilateral primary GSV varicosis.

Methods: Ninety-two patients were randomized for conventional (CON) or invaginated (INVAG) stripping and were followed for 26 weeks postoperatively.

Results: Both groups (n = 46) were well balanced for age, gender distribution, and body mass index. The CON group lost twice as much blood compared to the INVAG group (CON: 28 +/- 4 g, INVAG: 15 +/- 2 g, p < 0.001). Infragenual incision length following a conventional strip was twice as long (CON: 16 +/- 1 mm, INVAG: 8 +/- 1 mm, p < 0.001). Pain as measured with a visual analog scale (minimal 0, max 10) decreased in both groups in a similar fashion from 3.2 +/- 0.3 preoperatively to 0.6 +/- 0.2 after 26 weeks (p < 0.001). Saphenous nerve damage after one month was observed in four CON patients compared to no patients following invagination. Return to work was not different (CON: 13 +/- 2 days, INVAG: 11 +/- 2 days).

Conclusion: Invagination of the GSV in uncomplicated primary varicosis may be associated with less surgical trauma compared to a conventional stripping technique.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Loss, Surgical / statistics & numerical data
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement
  • Saphenous Vein / surgery*
  • Varicose Veins / surgery*
  • Vascular Surgical Procedures / adverse effects
  • Vascular Surgical Procedures / methods*