Brain atrophy in Werdnig-Hoffmann disease

Acta Neurol Scand. 1991 Nov;84(5):426-8. doi: 10.1111/j.1600-0404.1991.tb04982.x.


CT scan imaging of the brain was done in eight children with Werdnig-Hoffmann Disease. Seven of them showed generalized cerebral cortical atrophy and one had low attenuated, non-enhancing areas in the white matter involving both frontal lobes. These changes could be due to repeated episodes of hypoxic injury.

MeSH terms

  • Atrophy
  • Brain / pathology*
  • Cephalometry
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neurologic Examination
  • Spinal Muscular Atrophies of Childhood / pathology*
  • Tomography, X-Ray Computed*