The possible role of hyperhomocysteinemia on IVF outcome

J Assist Reprod Genet. 2007 Oct;24(10):459-62. doi: 10.1007/s10815-007-9165-2. Epub 2007 Sep 1.


Purpose: To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.

Method: Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.

Results: Pregnancy rate, implantation rate and abortion rate varied significantly (p<or=0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.

Conclusion: The results suggest that hyperhomocysteinemia could affect IVF outcome.

MeSH terms

  • Abortion, Spontaneous / etiology*
  • Adult
  • Embryo Implantation*
  • Female
  • Fertilization in Vitro*
  • Humans
  • Hyperhomocysteinemia / complications*
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate*