Nerve growth factor as an angiogenic factor

Microvasc Res. 2008 Mar;75(2):135-41. doi: 10.1016/j.mvr.2007.07.004. Epub 2007 Jul 21.


Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic and neurotropic effects in sympathetic neurons, has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. In fact, NGF may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenic Proteins / metabolism*
  • Animals
  • Cell Proliferation
  • Endothelial Cells / metabolism*
  • Humans
  • Ischemia / metabolism
  • Ischemia / physiopathology
  • Neoplasms / blood supply
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Pathologic / physiopathology
  • Neovascularization, Physiologic*
  • Nerve Growth Factor / metabolism*
  • Signal Transduction
  • Vascular Endothelial Growth Factor A / metabolism
  • Wound Healing


  • Angiogenic Proteins
  • Vascular Endothelial Growth Factor A
  • Nerve Growth Factor