Actin and Rho GTPases in herpesvirus biology

Trends Microbiol. 2007 Sep;15(9):426-33. doi: 10.1016/j.tim.2007.08.003. Epub 2007 Aug 30.


Viruses have evolved a variety of interactions with host cells to create an optimal niche for viral replication, persistence and spread. The actin cytoskeleton of the host cell and actin-regulating Rho GTPase signaling pathways can be involved in several of these interactions. This review focuses on recent findings on herpesvirus interactions with actin and Rho GTPases during viral entry, replication in the nucleus and egress. Unraveling these often fascinating interactions might also provide additional insights into sometimes poorly known aspects of actin biology (e.g. its role in the nucleus) and in the development of novel antiviral therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / physiology*
  • Animals
  • Capsid / physiology
  • Cell Nucleus / virology
  • Herpesviridae / physiology*
  • Humans
  • Signal Transduction
  • Virus Assembly
  • Virus Replication
  • rho GTP-Binding Proteins / physiology*


  • Actins
  • rho GTP-Binding Proteins