Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes

Clin Nutr. 2008 Feb;27(1):133-41. doi: 10.1016/j.clnu.2007.07.005. Epub 2007 Aug 31.


Background: The effects of different dietary fatty acids on postprandial lipid metabolism in type 2 diabetic patients are still debated.

Aim: To evaluate the effects of monounsaturated (MUFA) vs. saturated fat (SAFA)-rich diets on postprandial lipemia and adipose tissue lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in type 2 diabetes.

Materials and methods: Eleven type 2 diabetic patients followed, in random order, a diet rich in MUFA (SAFA 8%, MUFA 23%) and another rich in SAFA (SAFA 17%, MUFA 15%) for a period of 3 weeks each. At the end of the two diets, a standard fat-rich meal was administered and subcutaneous fat biopsies were performed at fasting and 6h after the test meal.

Results: Neither diet induced significant changes in meal lipid tolerance, except for a faster (at 2h) increase in chylomicron triglycerides and a significant decrease in small VLDL triglyceride incremental area after the MUFA diet (-13.6+/-4.7 mg/dl*6h vs. -2.2+/-3.7 mg/dl*6h, p<0.005) (M+/-SEM). LPL and HSL activities were significantly increased after the MUFA diet.

Conclusions: A MUFA-rich diet reduces postprandial small VLDL triglycerides in type 2 diabetic patients compared to a SAFA-rich diet, and modifies lipolytic enzymes in adipose tissue.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / enzymology
  • Area Under Curve
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / metabolism*
  • Dietary Fats / administration & dosage*
  • Dietary Fats, Unsaturated / administration & dosage*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Lipase / metabolism*
  • Lipid Metabolism / drug effects*
  • Lipoprotein Lipase / metabolism
  • Male
  • Middle Aged
  • Particle Size
  • Postprandial Period
  • Sterol Esterase / metabolism
  • Triglycerides / metabolism


  • Dietary Fats
  • Dietary Fats, Unsaturated
  • Triglycerides
  • Sterol Esterase
  • Lipase
  • Lipoprotein Lipase