Centrioles want to move out and make cilia

Dev Cell. 2007 Sep;13(3):319-21. doi: 10.1016/j.devcel.2007.08.007.

Abstract

Cilia formation in mammalian cells requires basal bodies that are either derived from centrioles that transition from their cytoplasmic role in centrosome organization or that form en masse in multiciliated cells. Several recent studies have begun to uncover the links between centriole duplication and their transformation to basal bodies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Aurora Kinases
  • Cell Cycle Proteins / metabolism
  • Centrioles / metabolism*
  • Centrosome / metabolism
  • Cilia / classification
  • Cilia / metabolism*
  • Cilia / physiology
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Models, Biological
  • Nuclear Proteins / metabolism
  • Phosphoproteins / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Tubulin / metabolism

Substances

  • CCP110 protein, human
  • Cell Cycle Proteins
  • Microtubule-Associated Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • Tubulin
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases