Post-transcriptional regulation of gene expression in trypanosomes and leishmanias

Mol Biochem Parasitol. 2007 Dec;156(2):93-101. doi: 10.1016/j.molbiopara.2007.07.007. Epub 2007 Jul 19.


Gene expression in Kinetoplastids is very unusual in that the open reading frames are arranged in long polycistronic arrays, monocistronic mRNAs being created by post-transcriptional processing. Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Leishmania / genetics*
  • Protein Biosynthesis
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / metabolism
  • RNA, Protozoan / metabolism
  • Trypanosoma / genetics*


  • RNA, Messenger
  • RNA, Protozoan