The SPFH domain-containing proteins: more than lipid raft markers

Trends Cell Biol. 2007 Aug;17(8):394-402. doi: 10.1016/j.tcb.2007.06.005. Epub 2007 Sep 4.


Membrane microdomains with distinct lipid compositions, called lipid rafts, represent a potential mechanism for compartmentalizing cellular functions within the plane of biological membranes. SPFH domain-containing proteins are found in lipid raft microdomains in diverse cellular membranes. The functions of these proteins are just beginning to be elucidated. Recent advances in the understanding of structural features and their roles within lipid rafts include a potential function for SPFH proteins in the formation of membrane microdomains and lipid raft-associated processes, such as endocytosis and mechanosensation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Intracellular Signaling Peptides and Proteins / chemistry
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Membrane Microdomains* / chemistry
  • Membrane Microdomains* / metabolism
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / metabolism
  • Prohibitins
  • Protein Isoforms / chemistry
  • Protein Isoforms / metabolism
  • Protein Structure, Tertiary*
  • Repressor Proteins / chemistry
  • Repressor Proteins / metabolism


  • ERLIN1 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • NPHS2 protein
  • Nerve Tissue Proteins
  • Prohibitins
  • Protein Isoforms
  • Repressor Proteins
  • STOM protein, human
  • flotillins