For IRES trans-acting factors, it is all about location

Oncogene. 2008 Feb 14;27(8):1033-5. doi: 10.1038/sj.onc.1210777. Epub 2007 Sep 3.


The translation of many proteins involved in transcription, cell cycle progression, apoptosis and cell survival is mediated by internal ribosome entry sites (IRESs) present within the 5'-untranslated regions (5'-UTRs) of their messenger RNA molecules (mRNAs). Several recent reports now demonstrate that the proteins controlling IRES-dependent translation initiation are regulated by their subcellular localization.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / physiology
  • Humans
  • Protein Biosynthesis / drug effects
  • Protein Biosynthesis / physiology
  • RNA, Messenger / physiology*
  • Ribosomes / metabolism*
  • Trans-Activators / physiology*
  • Vincristine / pharmacology


  • RNA, Messenger
  • Trans-Activators
  • Vincristine