Vascular endothelial growth factor promoted endothelial progenitor cell mobilization into the peripheral blood of a patient with POEMS syndrome

Haematologica. 2007 Sep;92(9):1291-2. doi: 10.3324/haematol.11455.


We assessed the percentage of endothelial progenitor cells (EPCs) in the peripheral blood of a patient with POEMS with elevated VEGF plasma levels. High VEGF plasma levels were associated with increased EPC concentration and treatment with an anti-VEGF antibody induced a consensual decrease of both parameters. In vitro cultures of the patient BM cells suggested that the stromal compartment could be responsible for VEGF overproduction.

Publication types

  • Letter

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Cell Movement*
  • Cells, Cultured
  • Endothelium, Vascular / cytology*
  • Endothelium, Vascular / metabolism
  • Humans
  • Neovascularization, Pathologic
  • POEMS Syndrome / blood*
  • POEMS Syndrome / drug therapy
  • POEMS Syndrome / pathology
  • Stem Cells / cytology*
  • Stem Cells / metabolism
  • Vascular Endothelial Growth Factor A / pharmacology*


  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Bevacizumab