Variant translocations of chromosome 13 in alveolar rhabdomyosarcoma

Genes Chromosomes Cancer. 1991 Nov;3(6):480-2. doi: 10.1002/gcc.2870030611.


In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the median age for patients with t(2;13)-positive alveolar rhabdomyosarcoma. The alteration of genetic material on chromosome 13 may be of primary importance in the development of alveolar rhabdomyosarcoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child, Preschool
  • Chromosomes, Human, Pair 1 / ultrastructure*
  • Chromosomes, Human, Pair 13 / ultrastructure*
  • Chromosomes, Human, Pair 2 / ultrastructure
  • Chromosomes, Human, Pair 8 / ultrastructure*
  • Female
  • Humans
  • Male
  • Rhabdomyosarcoma / genetics*
  • Soft Tissue Neoplasms / genetics*
  • Translocation, Genetic*