[Peptidergic modulation of the vagal effect on heart rhythm]

Biull Eksp Biol Med. 1991 Dec;112(12):565-7.
[Article in Russian]


In 20 experiments on anesthetised cats burst stimulation of peripheral cut end of right vagus nerve leads to synchronisation of cardiac and vagus rhythms. Inhibitory effect of dalargin was caused by a decrease of tonic component while secretin would selectively inhibit synchronizing component. The observed results testify to existence of selective peptidergic modulation of vagus influence on the cardiac rhythm.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cats
  • Electric Stimulation
  • Enkephalin, Leucine-2-Alanine / analogs & derivatives
  • Enkephalin, Leucine-2-Alanine / pharmacology
  • Female
  • Heart Rate* / drug effects
  • Heart Rate* / physiology
  • Male
  • Secretin / pharmacology
  • Sympatholytics / pharmacology
  • Vagus Nerve / drug effects
  • Vagus Nerve / physiology*


  • Sympatholytics
  • Secretin
  • Enkephalin, Leucine-2-Alanine
  • enkephalin-Leu, Ala(2)-Arg(6)-