[Peptidergic modulation of the vagal effect on heart rhythm]

Biull Eksp Biol Med. 1991 Dec;112(12):565-7.
[Article in Russian]

Abstract

In 20 experiments on anesthetised cats burst stimulation of peripheral cut end of right vagus nerve leads to synchronisation of cardiac and vagus rhythms. Inhibitory effect of dalargin was caused by a decrease of tonic component while secretin would selectively inhibit synchronizing component. The observed results testify to existence of selective peptidergic modulation of vagus influence on the cardiac rhythm.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cats
  • Electric Stimulation
  • Enkephalin, Leucine-2-Alanine / analogs & derivatives
  • Enkephalin, Leucine-2-Alanine / pharmacology
  • Female
  • Heart Rate* / drug effects
  • Heart Rate* / physiology
  • Male
  • Secretin / pharmacology
  • Sympatholytics / pharmacology
  • Vagus Nerve / drug effects
  • Vagus Nerve / physiology*

Substances

  • Sympatholytics
  • Secretin
  • Enkephalin, Leucine-2-Alanine
  • enkephalin-Leu, Ala(2)-Arg(6)-