Relationships of haptoglobin level to FEV1, wheezing, bronchial hyper-responsiveness and allergy

Clin Exp Allergy. 1991 Nov;21(6):669-74. doi: 10.1111/j.1365-2222.1991.tb03194.x.


The relationships of haptoglobin level to respiratory and allergic parameters have been assessed in an epidemiological study conducted in a working population surveyed twice 5 years apart. At the first survey conducted in 892 working men, haptoglobin level was significantly related to FEV1 (r = -0.18; P less than 0.001) and smoking habits. After adjustment for smoking, a history of wheezing was significantly related to lower haptoglobin level. A second survey conducted in 304 men of the original sample 5 years later confirmed that haptoglobin was related to FEV1 (r = -0.21; P less than 0.001) and that wheezing was significantly related to hypohaptoglobinaemia (lower decile; P = 0.04). Men who exhibited bronchial hyper-responsiveness to methacholine had haptoglobin levels 0.35 g/l higher than those who did not (P = 0.01). Haptoglobin level was unrelated to IgE level and skin prick tests. These results support the hypothesis of the role of inflammation in both lower lung function and bronchial hyper-responsiveness. They suggest that some heterogeneity exists within subjects with a history of wheezing.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Asthma / blood
  • Asthma / epidemiology
  • Bronchial Hyperreactivity / blood*
  • Bronchial Hyperreactivity / epidemiology
  • Bronchial Provocation Tests
  • Comorbidity
  • Forced Expiratory Volume*
  • Haptoglobins / analysis*
  • Humans
  • Hypersensitivity / blood*
  • Hypersensitivity / epidemiology
  • Male
  • Methacholine Chloride
  • Middle Aged
  • Orosomucoid / analysis
  • Respiratory Sounds*
  • Smoking
  • alpha 1-Antitrypsin / analysis


  • Haptoglobins
  • Orosomucoid
  • alpha 1-Antitrypsin
  • Methacholine Chloride